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Biocompatible palm stearin‐based polyesteramide as polymer carrier for solid dispersion
Author(s) -
Wong Wei Seng,
Lee Choy Sin,
Er Hui Meng,
Lim Wen Huei,
Wong Shew Fung
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.45892
Subject(s) - differential scanning calorimetry , materials science , polymer , nuclear chemistry , palm stearin , polymer chemistry , chemical engineering , chemistry , organic chemistry , physics , engineering , thermodynamics , food science , palm oil
Palm stearin‐based polyesteramide (PSPEA) was synthesized by reacting PS with diethanolamine, followed by azelaic acid at functionality molar ratio (OH: COOH) ranged 1:0.84 to 1:0.95 at 150–190 °C. FTIR, 1 H‐nuclear magnetic resonance, 13 C‐nuclear magnetic resonance, and gel permeation chromatography were used to elucidate the chemical structure and M w distribution of the PSPEA. PSPEA 4000 (acid value = 0.61 mg KOH/g sample, hydroxyl value = 51.97 mg KOH/g sample) was used in combination with stearic acid‐based PEA to prepare mefenamic acid (MA) solid dispersion. The solid dispersion demonstrated sixfold and twofold enhancement in T 50% and cumulative drug release as compared to pure MA. The differential scanning calorimetry and scanning electron microscopy analyses revealed solubilization of MA in PEA and transformation of MA into amorphous. In vitro cytotoxicity studies confirmed the safety profile of PSPEA against 3T3 fibroblast cell lines. This work demonstrated that the biocompatible PSPEA possesses surface tension lowering and anticrystallization effects have the potential as polymer carrier for pharmaceutical dosage forms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 45892.