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Drug delivery system based on poly(ether‐block‐amide) and acrylic acid for controlled release of vancomycin
Author(s) -
Ortega Alejandra,
MeléndezOrtiz H. Iván,
GarcíaUriostegui Lorena,
ÁvilaSoria Griselda
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.45745
Subject(s) - acrylic acid , fourier transform infrared spectroscopy , grafting , nuclear chemistry , drug delivery , polymer chemistry , materials science , vancomycin , monomer , scanning electron microscope , attenuated total reflection , chemistry , chemical engineering , organic chemistry , staphylococcus aureus , nanotechnology , composite material , polymer , bacteria , biology , engineering , genetics
Poly(ether‐block‐amide) (PEBA) films were grafted with acrylic acid (AAc) by gamma radiation, using the oxidative pre‐irradiation technique. The effect of dose, monomer concentration, temperature, and reaction time on the graft percentage of AAc onto PEBA was studied. The modified material PEBA‐g‐AAc was characterized by Fourier infrared spectroscopy (FTIR), scanning electron microscopy, and water contact angle. It was found that PEBA films did not suffer degradation at low doses (<30 kGy) during the grafting process. Additionally, PEBA‐g‐AAc was proved as drug delivery system using vancomycin as drug model. The PEBA‐g‐AAc with 39 and 98% of AAc loaded 63 and 98 mg g −1 , respectively. The release profiles showed a sustained delivery by 48 h with a partial retention of drug, which depends of grafting percentage. The microbiological tests showed that PEBA‐g‐AAc was able to inhibit the growing of Staphylococcus aureus in three consecutive challenges. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 45745.