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Heterogeneous hydrolytic degradation of poly(lactic‐ co ‐glycolic acid) microspheres: Mathematical modeling
Author(s) -
Busatto Carlos,
Pesoa Juan,
Helbling Ignacio,
Luna Julio,
Estenoz Diana
Publication year - 2017
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.45464
Subject(s) - autocatalysis , plga , degradation (telecommunications) , hydrolysis , hydrolytic degradation , polymer , glycolic acid , materials science , chemical engineering , microsphere , particle size , mass transfer , particle (ecology) , kinetics , polymer chemistry , chemistry , lactic acid , nanoparticle , chromatography , composite material , organic chemistry , nanotechnology , catalysis , computer science , physics , bacteria , oceanography , engineering , biology , genetics , telecommunications , quantum mechanics , geology
A new mathematical model for the prediction of the heterogeneous hydrolytic degradation of poly(D,L‐lactide‐ co ‐glycolide) (PLGA)‐based microspheres was developed. The model takes into account the autocatalytic effect of carboxylic groups and polymer composition on the degradation rate. It is based on mass balances for the different species, considering the kinetic and mass transport phenomena involved. The model estimates the evolution of average molecular weight, mass loss, and morphological change of the particles during degradation, and it was validated with novel experimental data. Theoretical predictions are in agreement with the hydrolysis data of PLGA microspheres (error values less than 5%). The model is able to predict the effect of particle size and molecular weight on the degradation of PLGA‐based microspheres and estimates the morphological changes of the particles due to the autocatalytic effect. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45464.