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Biomimetic porous collagen/hydroxyapatite scaffold for bone tissue engineering
Author(s) -
Chen Li,
Wu Zhenxu,
Zhou Yulai,
Li Linlong,
Wang Yu,
Wang Zongliang,
Chen Yue,
Zhang Peibiao
Publication year - 2017
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.45271
Subject(s) - scaffold , materials science , tissue engineering , porosity , biomedical engineering , alkaline phosphatase , bone tissue , nanotechnology , chemistry , composite material , engineering , biochemistry , enzyme
Bone defect and osteochondral injury frequently occur due to diseases or traumatism and bring a crucial challenge in orthopedics. The hybrid scaffold has shown promise as a potential strategy for the treatment of such defects. In this study, a novel biomimetic porous collagen (Col)/hydroxyapatite (HA) scaffold was fabricated through assembling layers of Col containing gradual amount of HA under the assistance of “iterative layering” freeze‐drying process. The scaffold presents a double gradient of highly interconnected porosity and HA content from top to bottom, mimicking the inherent physiological structure of bone. Owing to the biomimetic structure and component, significant increase of cell proliferation, alkaline phosphatase activity, and osteogenic differentiation in vitro was observed, illustrating potential application of the excellent Col/HA scaffold as a promising strategy for bone tissue engineering. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45271.