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Controlled heparinase‐catalyzed degradation of polyelectrolyte multilayer capsules with heparin as responsive layer
Author(s) -
Sun Lili,
Xiong Xin,
Zou Qiaogen,
Ouyang Pingkai,
Krastev Rumen
Publication year - 2017
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44916
Subject(s) - polyelectrolyte , allylamine , dextran , chitosan , materials science , chemical engineering , sulfonate , controlled release , polymer chemistry , confocal microscopy , chemistry , hydrochloride , polymer , chromatography , sodium , nanotechnology , organic chemistry , composite material , microbiology and biotechnology , biology , engineering
This work describes the enzymatic degradation of combined hollow capsules via layer‐by‐layer (LbL) self‐assembly technique. They previously showed the build‐up and characterization of capsules composed of synthetic [Poly(sodium 4‐styrene‐sulfonate)/Poly(allylamine hydrochloride)] and biodegradable (Heparin/Chitosan) polyelectrolytes. Biocatalytic response of assembled multilayer capsules provides a more functional and oriented approach in controlled release of encapsulated molecules: in this case multilayer capsule was disassembled by heparinase. Morphological change of individual capsule was assessed with Atomic Force Microscopy and Confocal Laser Scanning Microscopy. The sustained release of encapsulated FITC‐Dextran model was realized under enzymatic degradation of the capsule shells by heparinase. The release profile of FITC‐Dextran indicated the successful control in a concentration‐dependent manner, which shows the applicability as smart drug delivery system. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44916.