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Cover Image, Volume 134, Issue 18
Publication year - 2017
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44887
Subject(s) - self healing hydrogels , lysozyme , polymer , cover (algebra) , penetration (warfare) , citation , cancer therapy , computer science , chemistry , polymer science , chemical engineering , polymer chemistry , world wide web , biochemistry , mathematics , biology , operations research , cancer , organic chemistry , engineering , mechanical engineering , genetics
Co‐polymer hydrogels can be used for delivery of protein‐based therapeutics. Irina Ermolina and colleagues present the interaction of 2‐hydroxyethylmethacrylate‐2‐hydroxyethylacrylate (HEA‐HEMA) hydrogels with lysozyme as a small protein. An increase in effective pore network caused by hydrophilic HEA introduction promotes diffusive penetration of lysozyme and increases the rate of protein loading. The HEMA‐rich hydrogels are more suitable for sustained drug release, but impact on protein stability in the case of long‐term incubation. Proteins released from hydrogels with intermediate and high HEA content preserve their native conformation. (DOI: 10.1002/app.44768 )