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Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility
Author(s) -
Lee Il Woo,
Li Jinglei,
Chen Xiguang,
Park Hyun Jin
Publication year - 2017
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44859
Subject(s) - rutin , poloxamer , solubility , electrospinning , materials science , nanofiber , chemical engineering , bioavailability , antioxidant , scanning electron microscope , chromatography , nuclear chemistry , chemistry , organic chemistry , nanotechnology , polymer , composite material , copolymer , bioinformatics , engineering , biology
In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin‐Pluronic SDs (PUL&RU@PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL‐rutin‐Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44859.
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