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Evaluation of bioresorbable polymers as potential stent material— In vivo degradation behavior and histocompatibility
Author(s) -
Liao Lan,
Peng Cheng,
Li Suming,
Lu Zhiqian,
Fan Zhongyong
Publication year - 2017
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44355
Subject(s) - copolymer , materials science , molar mass , crystallinity , polymer , trimethylene carbonate , polymer chemistry , composite number , biodegradable polymer , polymerization , molar ratio , composite material , chemical engineering , chemistry , catalysis , organic chemistry , engineering
A PLLA‐TMC‐GA terpolymer of 90/5/5 molar ratio was synthesized by ring‐opening polymerization of l ‐lactide (LLA), trimethylene carbonate (TMC), and glycolide (GA), using stannous octoate as initiator. In vivo degradation of the obtained terpolymer and a composite made up of the terpolymer matrix reinforced by PLLA‐GA fibers was realized by subcutaneous implantation in rats for 9 months, in comparison with PLLA homopolymer and PLLA‐TMC copolymer of 95/5 molar ratio. The terpolymer shows ideal degradation profile because it is expected to maintain relatively high radial support for 3 months and lose its mechanical properties in 3 to 6 months inferred from molar mass changes. Increase of crystallinity and LLA content in the terpolymer and composite is observed during degradation. According to the gross observation and H&E staining appearance, all samples present good tissue compatibility. These results suggest that the terpolymer is promising for uses as fully biodegradable vascular scaffold. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 44355.