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Latex‐templated biomineralization of silica nanoparticles with porous shell and their application for drug delivery
Author(s) -
Zhou Huizhi,
Luo Jingchi,
Gao Qing,
Yang Tingting
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44200
Subject(s) - calcination , porosity , chemical engineering , nanoparticle , polystyrene , materials science , biomineralization , drug delivery , shell (structure) , chloride , nanotechnology , polymer chemistry , chemistry , organic chemistry , catalysis , composite material , polymer , engineering , metallurgy
A latex‐templating method for synthesizing the core‐shell silica nanoparticles (NPs) with porous shell was developed via biomineralization in the presence of poly[2‐(methacryloyloxy)ethyl] trimethylammonium chloride (pDMC)‐modified polystyrene latex. Calcination of the as‐obtained SiO 2 NPs led to the removal of the latex core and consequently to hollow silica NPs with porous shell. In particularly, the microstructure and thickness of silica shell could be controlled by simply changing the reaction parameters of silicification. Furthermore, facile encapsulation of a drug molecules and its sustained release were demonstrated. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 44200.