Premium
Electrospun poly(hydroxybutyrate)/chitosan blend fibrous scaffolds for cartilage tissue engineering
Author(s) -
Sadeghi Davoud,
Karbasi Saeed,
Razavi Shahnaz,
Mohammadi Sajjad,
Shokrgozar Mohammad Ali,
Bonakdar Shahin
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44171
Subject(s) - chitosan , ultimate tensile strength , materials science , electrospinning , tissue engineering , polyhydroxybutyrate , composite material , chemical engineering , fiber , polymer , biomedical engineering , medicine , engineering , biology , bacteria , genetics
In this study, polyhydroxybutyrate (PHB) was blended with chitosan (CTS), and electrospun in order to produce more hydrophilic fibrous scaffolds with higher mass loss rates for cartilage tissue engineering application. First, the effects of diverse factors on the average and distribution of fiber's diameter of PHB scaffolds were systematically evaluated by experimental design. Then, PHB 9 wt % solutions were blended with various ratios of CTS (5%, 10%, 15%, and 20%) using trifluoroacetic acid as a co‐solvent, and electrospun. The addition of CTS could decrease both water droplet contact angle from ∼74° to ∼67° and tensile strength from, ∼87 MPa to ∼31 MPa. According to the results, the scaffolds containing 15% and 20% CTS were selected as optimized scaffolds for further investigations. Mass loss percentage of these scaffolds was directly proportional to the amount of CTS. Chondrocytes attached well to the surfaces of these scaffolds. The findings suggested that PHB/CTS blend fibrous scaffolds have tremendous potentials for further investigations for the intended application. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 44171.