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Influence of structure on release profile of acyclovir loaded polyurethane nanofibers: Monolithic and core/shell structures
Author(s) -
Azizi Maryam,
Seyed Dorraji Mir Saeed,
Rasoulifard Mohammad Hossein
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.44073
Subject(s) - nanofiber , materials science , polyurethane , core (optical fiber) , electrospinning , composite material , fourier transform infrared spectroscopy , shell (structure) , diffusion , chemical engineering , polymer chemistry , polymer , physics , engineering , thermodynamics
In this study, monolithic and core/shell polyurethane (PU) nanofibers were fabricated by single and coaxial electrospinning techniques, respectively. An antivirus drug, Acyclovir (ACY), was loaded on PU nanofibers. The physical condition and interaction of the loaded ACY within these nanofibers were studied by FTIR, XRD, DSC, SEM, and TEM. In vitro tests exhibited an obvious difference in the release pattern between monolithic and core/shell nanofibers and burst release in monolithic nanofibers could be controlled by core/shell structure. Release profile was found to follow Korsmeyere‐Peppas model with Fickian diffusion mechanism. Our study demonstrated that the ACY‐loaded core/shell nanofibers might serve as a device for drug delivery systems. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 44073.