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5‐Fluorouracil encapsulated magnetic nanohydrogels for drug‐delivery applications
Author(s) -
Jayaramudu Tippabattini,
Raghavendra Gownolla Malegowd,
Varaprasad Kokkarachedu,
Raju Konduru Mohana,
Sadiku Emmanuel Rotimi,
Kim Jaehwan
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43921
Subject(s) - fourier transform infrared spectroscopy , materials science , magnetic nanoparticles , drug delivery , transmission electron microscopy , scanning electron microscope , acrylamide , nuclear chemistry , ferric , polymerization , chemical engineering , analytical chemistry (journal) , nanoparticle , nanotechnology , polymer chemistry , chemistry , copolymer , organic chemistry , polymer , composite material , engineering , metallurgy
For the first time, green‐tea (GT)‐based magnetic nanohydrogels were developed for drug‐delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5‐fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43921.