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Manipulation of the drug‐release behavior of poly(glycolide‐ co ‐trimethylene carbonate)
Author(s) -
Nochos Argyrios N.,
Andrikopoulos Konstantinos S.,
Voyiatzis George A.
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43915
Subject(s) - crystallinity , materials science , dispersion (optics) , differential scanning calorimetry , fourier transform infrared spectroscopy , polymer , chemical engineering , dissolution , polymer chemistry , composite material , optics , physics , engineering , thermodynamics
The current work focuses on Maxon, a modern biocompatible/bioabsorbable polymer, utilized in the fabrication of surgical sutures, and attempts to explore the limits of controlling the administration rate of a properly incorporated model drug, mitoxandrone dihydrochloride. The control is attempted by tailoring both the structural properties of the host polymer, more specifically its crystallinity and anisotropy, and the level of drug dispersion achieved after following different incorporation methods such as melt and dissolution mixing. The results, based on optical and electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, and UV–vis spectroscopy, indicate that the structural parameters invoked may enable fine‐tuning of the drug dose released within a 60‐day period. Additionally, the burst effect of the active agent at the early stages of release is regulated by adjusting the drug dispersion level. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43915.