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Development of biodegradable polymeric nanoparticles for encapsulation, delivery, and improved antifungal performance of natamycin
Author(s) -
Bouaoud Clotilde,
Xu Sala,
Mendes Eduardo,
Lebouille Jérôme G. J. L.,
De Braal Henriette E. A.,
Meesters Gabriel M. H.
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43736
Subject(s) - natamycin , nanoparticle , antifungal , polymer , materials science , controlled release , biodegradable polymer , plga , chemical engineering , kinetics , chemistry , nanotechnology , food science , microbiology and biotechnology , composite material , physics , engineering , quantum mechanics , biology
The aim of this study was to evaluate biodegradable poly(lactide‐co‐glycolide) nanoparticles as potential nano‐delivery systems for the food antifungal compound natamycin. Natamycin‐loaded nanoparticles were prepared at various ratios polymer/antifungal by the nanoprecipitation technique, resulting in nano‐size particles (80–120 nm) with a narrow distribution and a spherical morphology. Complexation of natamycin with PLGA and active participation to the nanoparticle formation were evidenced by a mean diameter reduction of 10–30 nm, although encapsulation levels remained low due to the zwitterionic and partially hydrophilic nature of natamycin. Physical state analyses highlighted the presence of natamycin in an amorphous or molecularly dispersed state within the polymeric matrix. This translates into high availability of free antifungal molecules reflected in burst release and fast in vitro release kinetics rates as well as enhanced antifungal performance against the model food yeast Saccharomyces cerevisiae , offering a potential benefit for antifungal protection compared with the commercially available natamycin products. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43736.