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Carboxymethyl sago pulp/carboxymethyl sago starch hydrogel: Effect of polymer mixing ratio and study of controlled drug release
Author(s) -
Tan Hui Li,
Wong Yeon Yin,
Muniyandy Saravanan,
Hashim Kamaruddin,
Pushpamalar Janarthanan
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43652
Subject(s) - self healing hydrogels , swelling , differential scanning calorimetry , materials science , distilled water , polymer , starch , chemical engineering , scanning electron microscope , nuclear chemistry , chemistry , polymer chemistry , composite material , chromatography , organic chemistry , physics , engineering , thermodynamics
Carboxymethyl sag o pulp (CMSP)/carboxymethyl sago starch (CMSS) hydrogel was synthesized by electron beam irradiation. In the series of hydrogels prepared, 40%/20% CMSP/CMSS hydrogel had the highest gel fraction. The swelling capacity of CMSP/CMSS hydrogel was found to be highest in distilled water, followed by pH 11, pH 7.4, and pH 1.2. Scanning Electron Microscope photographs revealed that the drug‐loaded hydrogel had a smoother surface than unloaded hydrogel. Fourier Transform Infrared and Differential Scanning Calorimetry analysis showed the absence of interaction between the hydrogels and the drug. All drug‐loaded hydrogels had drug encapsulation efficiency between 63% and 69%. CMSP/CMSS hydrogel swelled and allowed the release of drug at pH 7.4. These properties qualify the hydrogel as a potential candidate for controlled drug release at the ocular and colonic regions. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43652.