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Electron beam sterilization of cyclo olefin polymer leads to polymer degradation and production of alkyl radicals
Author(s) -
Kiminami Hideaki,
Imae Yasufumi,
Takahashi Eiji,
Wei Hong,
Oomura Satoshi,
Abe Yoshihiko
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43498
Subject(s) - radical , alkyl , mass spectrometry , polymer , chemistry , olefin fiber , sterilization (economics) , methanol , mass spectrum , polymer chemistry , analytical chemistry (journal) , nuclear chemistry , chromatography , organic chemistry , foreign exchange , monetary economics , economics , foreign exchange market
We investigated the effects of electron‐beam (EB) sterilization on syringe barrels manufactured from cyclo olefin polymer (COP). The chemical structure of the polymer was determined by interpreting the 13 C NMR and DEPT‐135 spectra of the COP resin. The antioxidants in the resin were identified by analyzing the liquid chromatography‐photo diode array‐mass spectrometry (LC‐PDA‐MS) data for the methanol extract of the resin and the gas chromatography‐mass spectrometry (GC‐MS) data for the supercritical methanol degradation products of the extract. NMR and LC‐PDA‐MS analyses revealed that EB sterilization produces degradation products in the COP main chain and reduces the quantity of the antioxidants in the COP resin. ESR spectra of the EB‐sterilized syringe barrels indicated the presence and location of alkyl radicals, which were generated in the COP main chain by EB sterilization. ESR analyses also indicated that the quantity of alkyl radicals decreased over time. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43498.