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Facile synthesis of biocompatible polyglycerol hydrogel based on epichlorohydrin
Author(s) -
Yang Q. Z.,
Fan C. J.,
Yang X. G.,
Liao L. Q.,
Liu L. J.
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43451
Subject(s) - epichlorohydrin , self healing hydrogels , ethylene glycol , fourier transform infrared spectroscopy , swelling , polymer chemistry , materials science , chemical engineering , nuclear chemistry , nuclear magnetic resonance spectroscopy , biocompatible material , x ray photoelectron spectroscopy , chemistry , organic chemistry , composite material , biomedical engineering , medicine , engineering
A series of hydrophilic polyglycerol (PG) hydrogel was designed and synthesized via one pot with epichlorohydrin (ECH), H 2 O, and NaOH as the starting materials. The equilibrium swelling ratios of PG hydrogels could be tuned by simply changing the feed amount of NaOH. The gels were characterized by carbon nuclear magnetic resonance ( 13 C NMR) spectroscopy, X‐ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. The As‐synthesized PG hydrogels showed temperature‐sensitive swelling behaviors. The results of MTT assay suggested that the PG hydrogels prepared by this novel synthesis method showed comparable cytocompatibility with the recognized poly(ethylene glycol) hydrogel. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43451.