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Synthesis, characterization, and cytotoxicity of star‐shaped polyester‐based elastomers as controlled release systems for proteins
Author(s) -
Guo Fangyuan,
Zhang Wei,
Pei Xiaohong,
Shen Xia,
Yan Qinying,
Hong Weiyong,
Yang Gensheng
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43393
Subject(s) - caprolactone , polyester , bovine serum albumin , biocompatibility , ethylene glycol , polymer chemistry , elastomer , controlled release , drug delivery , materials science , hydrolysis , poly(methacrylic acid) , methacrylic acid , chemistry , polymerization , polymer , organic chemistry , biochemistry , nanotechnology
With the growing number of therapeutic proteins on the market, effective delivery systems are receiving particular attention. In this study, biodegradable elastomers, intended for protein drug delivery and based on methacrylic tripoly(ε‐caprolactone‐ co ‐ d , l ‐lactide) cyclic ester with different ratios of ɛ‐caprolactone to d , l ‐lactide and methacrylic bipoly[ɛ‐caprolactone‐ b ‐poly(ethylene glycol)‐ b ‐ɛ‐caprolactone], were synthesized and characterized. The degradation behavior, bovine serum albumin (BSA)‐releasing kinetics, and cytotoxicity of the elastomers in vitro were investigated. The elastomers were degraded by the hydrolysis of the ester bond; this resulted in pH changes, which further affected the degradation rate. The BSA‐releasing behavior was strongly dependent on the diffusion mechanism. In the diffusion‐controlled period, nearly sustained and stable BSA release was achieved. Furthermore, the elastomers displayed good biocompatibility, as demonstrated by a 3‐(4,5‐dimethyl thiazol‐2‐yl)−2,5‐diphenyl tetrazolium bromide assay and inflammation–induction experiments, and are considered promising candidates for the controllable delivery of protein drugs. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43393.