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Controlled release of protein from magnetite–chitosan nanoparticles exposed to an alternating magnetic field
Author(s) -
Honarmand Dariush,
Ghoreishi Seyyed M.,
Habibi Neda,
Nicknejad Ehsan Tayerani
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43335
Subject(s) - chitosan , nanoparticle , magnetic nanoparticles , bovine serum albumin , magnetite , materials science , controlled release , fourier transform infrared spectroscopy , chemical engineering , nanotechnology , nuclear magnetic resonance , analytical chemistry (journal) , chemistry , chromatography , physics , engineering , metallurgy
ABSTRACT In this research, the controlled release of proteins from magnetite (Fe 3 O 4 )–chitosan (CS) nanoparticles exposed to an alternating magnetic field is reported. Fe 3 O 4 –CS nanoparticles were synthesized with sodium tripolyphosphate (TPP) molecules as a crosslinking reagent. Bovine serum albumin (BSA) was used as a model protein, and its controlled release studied through the variation of the frequency of an alternating magnetic field. The results show the successful coating of CS and BSA on the Fe 3 O 4 nanoparticles with an average diameter of 50 nm. Intermolecular interactions of TPP with CS and BSA were confirmed by Fourier transform infrared spectroscopy. The application of low‐frequency alternating magnetic fields to such magnetic CS nanoparticles enhanced the protein release properties, in which the external magnetic fields could switch on the unloading of these nanoparticles. We concluded that enhanced BSA release from nanoparticles exposed to an alternating magnetic field is a promising method for achieving both the targeted delivery and controlled release of proteins. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43335.