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In vitro nifedipine release from poly(lactic acid)/chitosan nanoparticles loaded with nifedipine
Author(s) -
Chinh Nguyen Thuy,
Trang Nguyen Thi Thu,
Giang Nguyen Vu,
Thanh Dinh Thi Mai,
Hang To Thi Xuan,
Tung Nguyen Quang,
Truyen Chu Quang,
Quan Pham Minh,
Long Pham Quoc,
Hoang Thai
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43330
Subject(s) - nifedipine , chitosan , in vitro , lactic acid , nanoparticle , chemistry , materials science , calcium , nanotechnology , biochemistry , organic chemistry , bacteria , biology , genetics
In this study, nanoparticles based on poly(lactic acid) (PLA), chitosan (CS), and nifedipine (NIF) were prepared by an emulsion method with poly(ethylene oxide) (PEO) as an emulsifier. We investigated the most suitable conditions for preparing the poly(lactic acid)/chitosan/nifedipine nanoparticles (PCNs) by changing the distilled water volume, PEO content, and PLA/CS ratio. NIFs with different contents were loaded into poly(lactic acid)/chitosan nanoparticles (PCs) to study in vitro drug‐delivery systems. The PCNs were characterized with a Zetasizer particle size analyzer, field emission scanning electron microscopy, Fourier transform infrared (FTIR) spectroscopy, and X‐ray diffraction (XRD) methods. From the obtained results of the particle size parameters of the PCNs, the most suitable conditions for the preparation of the PCNs were found. The FTIR spectroscopy and XRD results show that NIF was loaded into the PCs. The PCNs had major basic particle sizes in the range 20–40 nm. NIF release from the PCNs was studied as a function of the pH of the immersed solution, the immersion time, and the NIF content. The kinetics of drug release were investigated and are reported to determine the type of release mechanism. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43330.