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Rheological study of copovidone and solid dispersion blend used for hot melt extrusion
Author(s) -
Dudhedia Mayur S.,
Agrawal Anjali M.
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43278
Subject(s) - extrusion , rheology , materials science , dispersion (optics) , composite material , polymer science , optics , physics
The focus of this work is to generate rheological parameters using AR 2000EX rheometer for PVP VA64 and Compound A – PVP VA64 blend at different temperatures, which can then be subsequently used to identify hot melt extrusion process conditions. Addition of Compound A to the neat PVP VA64 shows a drop in storage modulus and loss modulus as compared to the neat PVP VA64. It appears that Compound A is acting as a plasticizer by increasing the separation of the polymer chains and thus results in reduction of viscosity of Compound A blends compared to polymer only samples. For both systems, based on low standard error of fit, Cross model was chosen as the best fit for the rheological data and temperature dependency of viscosity was assessed by Williams–Landel–Ferry (WLF) model. This approach can be applied to screen formulations with new chemical entities (NCEs) and generate rheological information with various extruding polymers at fixed/variable drug loading in polymer matrix to determine suitability for hot melt extrusion process and appropriate temperature for conducting hot melt extrusion. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43278.