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Design and in vitro investigation of nanocomposite hydrogel based in situ spray dressing for chronic wounds and synthesis of silver nanoparticles using green chemistry
Author(s) -
Kumar Arun,
Jaiswal Maneesh
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43260
Subject(s) - zeta potential , polyvinyl alcohol , silver nanoparticle , swelling , nanocomposite , aqueous solution , distilled water , chemical engineering , acrylic acid , boric acid , chemistry , materials science , fourier transform infrared spectroscopy , nanoparticle , nuclear chemistry , calcium alginate , polymer chemistry , composite material , nanotechnology , polymer , chromatography , organic chemistry , calcium , copolymer , engineering
An innovative concept of spontaneous film dressing has been designed as sprayed hydrogel dressings (SHD) using a blend of polyvinyl alcohol (PVA) and sodium alginate (SA) as synthetic and natural polymeric components and, were crosslinked with boric acid and calcium chloride, respectively. Silver nanoparticles (AgNPs) are synthesized by green chemistry using Ficus benghalensis extract (FB) and were characterized by SEM and zeta sizer. FTIR spectra show polymeric interaction with AgNP s , while SEM images show outer surface of the SHD film. Equilibrium swelling and degradation in aqueous media (distilled water and buffers) are found to be dependent upon PVA/SA ratio. Polymeric combination exhibit pseudoplastic behavior with Farrow's constant >1. Uniformly distributed AgNPs (particle size ∼27.55 ± 2.01 nm), high water retention (∼13 fold), and biodegradable (∼5 days) nature of dressing along with sustained release profile of both AgNPs and extract with concentration‐dependent antimicrobial activity have been observed for 24 h. Self shaped, biodegradable, aseptic, prolong anti‐oxidative, non‐hemolytic, blood compatible, and hemostatic properties of SHD film appears as promising dressing for superficial wounds. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43260.