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Preparation and characterization of p H responsive poly(methacrylic acid‐acrylamide‐ N ‐hydroxyethyl acrylamide) hydrogels for drug delivery systems
Author(s) -
Bal Ayça,
Özkahraman Bengi,
Özbaş Zehra
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.43226
Subject(s) - self healing hydrogels , acrylamide , swelling , methacrylic acid , drug delivery , poly(methacrylic acid) , polymer chemistry , radical polymerization , polymer , fourier transform infrared spectroscopy , polymerization , nuclear chemistry , chemistry , materials science , chemical engineering , organic chemistry , monomer , composite material , engineering
In this study, pH responsive polymers composed of methacrylic acid, acrylamide, and N‐hydroxyethyl acrylamide were synthesized by free radical polymerization technique. The characterization was done with Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling and drug release behavior of the hydrogels was determined as a function of time at 37°C in pH 2.1 and 7.4. The swelling and drug release studies showed that increased methacrylic acid amount caused a higher increase in swelling and drug release values at pH 7.4 than those at pH 2.1. In addition, the drug release data were applied to kinetic models such as zero order, first order, and Higuchi equations, and it fit well in the Higuchi model of the hydrogel. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43226.