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Complex aggregates formed with a hyperbranched polyglycerol derivative for drug delivery
Author(s) -
Zheng Qianqian,
Zhou Xiaoyan,
Li Hui,
Ma Dong,
Xue Wei
Publication year - 2016
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42895
Subject(s) - amphiphile , dynamic light scattering , glycidol , drug delivery , copolymer , polymersome , monomer , polymer chemistry , materials science , hemolysis , drug carrier , poloxamer , thromboelastography , polymer , drug , chemistry , nanoparticle , organic chemistry , nanotechnology , coagulation , pharmacology , immunology , catalysis , biology , medicine , psychology , psychiatry
An amphiphilic hyperbranched polyglycerol derivative (HPG‐C18) was synthesized by the anionic ring‐opening copolymerization with glycidol and 1,2‐epoxyloctadecane as the monomers. This hyperbranched polymer formed large complex aggregates as confirmed by dynamic light scattering and transmission electron microscopy tests. Because of its amphiphilic properties, HPG‐C18 was explored to load hydrophobic docetaxel, a clinical antitumor drug, and deliver it into breast cancer cell line (MCF‐7) cells. To investigate the application of the aggregates in drug delivery, blood compatibility was studied by hemolysis analysis, red blood cell observation, and thromboelastography assay. These results indicate that HPG‐C18 inhibited MCF‐7 proliferation effectively with good blood compatibility, and this suggested a potential application in tumor therapy. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 42895.