Premium
Synthesis of chitosan derivative with dual‐antibacterial functional groups and its antibacterial activity
Author(s) -
Li Zhihan,
Yang Fei,
Yang Rendang
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42663
Subject(s) - chitosan , antibacterial activity , zeta potential , nuclear chemistry , solubility , chemistry , escherichia coli , thermal stability , antimicrobial , antibacterial agent , x ray photoelectron spectroscopy , derivative (finance) , materials science , bacteria , organic chemistry , nanotechnology , nanoparticle , biochemistry , chemical engineering , biology , antibiotics , genetics , gene , financial economics , engineering , economics
The O‐fumaryl ester (OFTMCS) of N,N,N‐trimethyl chitosan (TMCS) has been synthesized as a water‐soluble chitosan (CS) derivative bearing dual‐functional groups, with the aim of discovering novel CS derivatives with good water solubility and enhanced the antibacterial activity compared with unmodified CS. OFTMCS was characterized by FT‐IR, 13 C NMR, XPS, XRD and Zeta potential analyses. The XPS results indicated that the degree of substitution (DS) on the C 2 ‐NH 2 group of the CS was 0.78, and that the DS on its C 6 ‐OH group was 0.31. The TGA results showed that the thermal stability of OFTMCS was lower than that of unmodified CS. The antibacterial activities of OFTMCS were investigated by assessing the mortality rates of the representative Gram‐positive and Gram‐negative bacteria Staphylococcus aureus and Escherichia coli , respectively. The results indicated that OFTMCS exhibited superior antibacterial activity to CS at a lower dosage. The synthesis of CS derivatives bearing dual‐functional groups could therefore be used as a promising strategy to enhance the antibacterial activity of CS. The antimicrobial mechanism of action of OFTMCS was discussed. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42663.