z-logo
Premium
PEGylated chitosan microspheres as mucoadhesive drug‐delivery carriers for puerarin
Author(s) -
Hu Xiaofen,
Zhang Yuyan,
Zhou Huifen,
Wan Haitong
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42623
Subject(s) - puerarin , chitosan , mucoadhesion , swelling , ethylene glycol , drug delivery , drug carrier , pegylation , chemistry , materials science , peg ratio , chemical engineering , chromatography , polyethylene glycol , nanotechnology , organic chemistry , composite material , medicine , alternative medicine , pathology , finance , engineering , economics
PEGylated chitosans with different degrees of grafting were synthesized, and the application potential of microspheres based on PEGylated chitosan as mucoadhesive drug‐delivery carriers for puerarin was investigated. Compared with chitosan microspheres, PEGylated chitosan microspheres (PCMs) exhibited better physical stability and higher swelling capacity, and the amount of water uptake increased as the content of poly(ethylene glycol) methyl ether in the microspheres increased. PCMs showed obviously improved mucoadhesive behavior on a mucosa‐like surface. Puerarin was incorporated into the microspheres, and the release experiments in vitro showed that the PEGylation of chitosan accelerated puerarin release from the particles and decreased the retention of the drug. The abilities of all of the tested microspheres to open tight junctions and improve the permeability of puerarin were demonstrated with a Caco‐2 cell monolayer as an in vitro model. The amount of puerarin permeating across the Caco‐2 cell monolayer was significantly increased by the incorporation of puerarin into the PCMs. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42623.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here