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Thermoresponsive hollow magnetic microspheres with hyperthermia and controlled release properties
Author(s) -
Chen Lin,
Zhang Huan,
Li Longfei,
Yang Yongzhen,
Liu Xuguang,
Xu Bingshe
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42617
Subject(s) - materials science , polymer , magnetic hyperthermia , polymerization , nanoparticle , chemical engineering , magnetism , nanomaterials , magnetic nanoparticles , polymer chemistry , nanotechnology , composite material , physics , quantum mechanics , engineering
ABSTRACT Thermoresponsive hollow magnetic microspheres consisting of a hollow magnetic core, a carbon shell, and a smart polymer layer are presented in this article. A carbon nanomaterial was used as a steric stabilizer for Fe 3 O 4 nanoparticles and a supporter for polymer. The thermoresponsive monomer, N ‐isopropyl acrylamide, was grafted on the carbon‐encapsulate hollows by surface radical polymerization. The experimental results indicate that the composites had a phase‐transition temperature around 43°C and a saturation magnetization of 56.9 emu/g; this showed apparent thermosensitivity and magnetism. The performances in hyperthermia evaluated by an inductive magnetic field showed that the hybrid microspheres had a specific absorption rate of 240 W/g. The model drug, 5‐fluorouracil, was loaded in and released from the microspheres with different release rates at 35 and 50°C. This demonstrated that the as‐synthesized microspheres had a thermotriggered release ability and would be a good drug carrier in the biomedical field. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42617.