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Interactions in blends of dendronized polymeric nanocomposites with some common drugs
Author(s) -
Alvarado Nancy,
Fuentes Irma,
Alegría Luz,
Sandoval Claudia,
Kortabería Galder,
Eceiza Arantxa,
Gargallo Ligia,
Leiva Angel,
Radić Deodato
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42450
Subject(s) - methacrylamide , thermogravimetric analysis , polymer , materials science , monomer , nanocomposite , polymer chemistry , polymer blend , chemical engineering , phase (matter) , copolymer , chemistry , nanotechnology , organic chemistry , composite material , acrylamide , engineering
Poly(diethylaminoethyl methacrylamide) (PEAM), a dendronized polymer, was synthesized according to classical procedures. Monomers and polymers were characterized by spectroscopic measurements. The results obtained were in agreement with the expected chemical structure. The phase behavior of blends of PEAM with diclofenac (DCF), ibuprofen (IBU) , and paracetamol (PCM) were studied by different experimental techniques. FT‐IR, UV‐Vis, DSC , and TGA measurements suggested important interactions between the blended components. Thermogravimetric analysis (TGA) indicated the temperature at which the dendronized polymer released a small molecule. AFM measurements and molecular dynamics (MD) simulations were used to better understand the nature of the interactions and to estimate the distance between the components of the blends to explain the interaction involved. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42450.