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Carbohydrate crosslinked biocompatible polyurethanes: Synthesis, characterization, and drug delivery studies
Author(s) -
Solanki Archana Ritesh,
Kamath Bolavinayak V.,
Thakore Sonal
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42223
Subject(s) - biocompatibility , thermogravimetric analysis , differential scanning calorimetry , polyol , materials science , scanning electron microscope , drug delivery , polymer , fourier transform infrared spectroscopy , kinetics , chemical engineering , polymer chemistry , drug carrier , nuclear chemistry , polyurethane , chemistry , nanotechnology , composite material , physics , quantum mechanics , engineering , metallurgy , thermodynamics
A series of novel polyurethanes (PUs) with carbohydrate crosslinkers was synthesized. The drug loading and release kinetics were studied by using lamotrigine as a model drug. The polymers were designed in such a way that the drug release was tailored by differences in the stoichiometry of polymers. All the PUs were characterized for thermal and morphological properties by using differential scanning calorimetry and thermogravimetric analysis and scanning electron microscope , respectively. The encapsulation of drug inside PU matrix was confirmed via Fourier transform ‐ infrared (FT‐IR) spectra and scanning electron microscope . The kinetics and release mechanisms were observed to be a function of stoichiometric parameters such as type of crosslinker, polyol/crosslinker ratio and polyol/chain extender ratio. All the PUs were observed to be non‐cytotoxic in normal lung cell line L132. The synthesized PUs exhibited good mechanical strength, tunable release rates and biocompatibility that can be utilized in biomedical applications like wound dressing, biomedical implants , and drug delivery carriers. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42223.