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In vivo bioactivity of herbal‐drug‐incorporated nanofibrous matrixes
Author(s) -
Agnes Mary S.,
Giri Dev V. R.
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42178
Subject(s) - polycaprolactone , in vivo , electrospinning , absorption of water , materials science , aloe vera , wound healing , biomedical engineering , permeability (electromagnetism) , chemical engineering , composite material , chemistry , traditional medicine , membrane , surgery , medicine , polymer , biochemistry , microbiology and biotechnology , engineering , biology
Aloe‐vera‐incorporated polycaprolactone nanofibrous matrixes were prepared by an electrospinning method. These developed matrixes were evaluated for their water absorption capacity, water vapor permeability, and contact angle, and, in an in vivo animal model, wound‐healing ability. The incorporation of the herbal drug made the matrixes hydrophilic with improved water retention and permeability properties. The in vivo studies were carried out in a rat model and showed improved results with respect to healing. Thus, this study confirmed that the developed matrixes could be used for wound‐healing applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42178.