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Controlled drug release of silicone‐based adhesive‐containing cross‐linked siloxane powders as a reservoir
Author(s) -
Kim Cheol Hyun,
Lee Su Jung,
Gwak GyeongHyeon,
Kim Tae Woo,
Cho Hyeon Mo,
Oh Jae Min,
Lee Myong Euy
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42154
Subject(s) - siloxane , hydrosilylation , polydimethylsiloxane , silicone , adhesive , transdermal , materials science , copolymer , silicone oil , polymer chemistry , organic chemistry , composite material , chemistry , polymer , catalysis , medicine , layer (electronics) , pharmacology
ABSTRACT We prepared pressure‐sensitive adhesive (PSA)‐containing cross‐linked siloxane powders (CS) as a reservoir for a transdermal drug delivery system (TDDS) and evaluated their sustained drug‐release properties. PSA, as a patch‐type adhesive, was synthesized by a hydrosilylation reaction of vinyl‐terminated polysiloxanes with hydrogen‐terminated polydimethylsiloxanes. CS was also prepared via a hydrosilylation process with vinyl‐terminated polydimethylsiloxane, 1,3,5,7‐tetramethyl‐1,3,5,7‐tetravinyltetracyclosiloxane ( D 4 Vi), hydrogen‐terminated polydimethylsiloxane, and dimethylhydrogenmethyl oligomeric siloxane copolymer. The results of release performances using ascorbic acid as a model drug showed a cumulative linear slope over a week, indicating a constant release performance. Our data suggest that this siloxane TDDS could be useful for constant drug release over a long period. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42154.