Premium
Synthesis, characterization, and in vitro drug release study of 3‐arm poly‐β‐alanine
Author(s) -
Kumar Krishna,
Adhikary Pubali,
Tungala Kranthikumar,
Azmeera Venkanna,
Krishnamoorthi S.
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.42124
Subject(s) - acrylamide , proton nmr , diclofenac sodium , sodium azide , nuclear chemistry , monomer , polymer chemistry , drug delivery , propargyl alcohol , chemistry , nucleophilic substitution , polymerization , polymer , materials science , stereochemistry , organic chemistry , chromatography , catalysis
Synthesis of three arms star‐shaped poly‐β‐alanine (3‐b‐ala) based on tri(prop‐2‐yn‐1‐yl) benzene‐1,3,5‐tricarboxylate (TBT) and azido terminated poly‐β‐alanine (N 3 ‐P‐ala) was performed using click reaction. TBT was synthesized by nucleophilic substitution reaction between propargyl alcohol and 1,3,5‐benzenetricarbonyltrichloride. For the first time, N 3 ‐P‐ala was synthesized through anionic polymerization of acrylamide using sodium azide as an initiator. TBT was characterized by FT‐IR and 1 HNMR. N 3 ‐p‐ala was characterized by FT‐IR, GPC, and 1 HNMR and 3‐b‐ala was characterized by FT‐IR, GPC, 1 HNMR, TGA, and XRD. The synthesized 3‐b‐ala was used for drug loading and releasing studies. Polymer loaded drug (3‐b‐ala‐D) hybrid was used in in vitro studies of drug (Diclofenac sodium) release in phosphate buffer solution (PBS) at 37 ± 0.5°C and pH 7.4. The drug loading and releasing studies were analyzed by UV‐visible spectrophotometer. 3‐b‐ala‐D was examined by AFM to analyze the surface morphology and roughness. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42124.