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Salt and pH sensitive semi‐interpenetrating polyelectrolyte hydrogels poly(HEMA‐ co ‐METAC)/PEG and its BSA adsorption behavior
Author(s) -
Hu YanYan,
Zhang Jing,
Fang QiChen,
Jiang DongMei,
Lin ChuCheng,
Zeng Yi,
Jiang JiSen
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.41537
Subject(s) - thermogravimetric analysis , polyelectrolyte , materials science , polymer chemistry , self healing hydrogels , methacrylate , swelling , chemical engineering , peg ratio , cationic polymerization , thermal stability , adsorption , monomer , polymer , polyethylene glycol , protein adsorption , chemistry , organic chemistry , composite material , finance , engineering , economics
A novel semi‐interpenetrating poly(2‐hydroxyethyl methacrylate) (pHEMA) based polyelectrolyte hydrogel [p(HEMA‐ co ‐METAC)/PEG] was prepared by copolymerizing HEMA with the cationic monomer 2‐methacryloyloxyethyltrimethyl ammonium chloride (METAC) in the presence of polyethylene glycol (PEG) with different content and molecular weight (MW 4000 and 400). The chemical structure of the gels was confirmed by FT‐IR spectroscopy, morphology study was performed by scanning electron microscope (SEM), thermal stability was revealed by thermogravimetric analysis (TGA), and the mechanical properties were determined by electronic universal testing machine. Swelling studies showed introduction of cationic monomer METAC led to high water content, and the obvious salt and pH sensitive properties were observed which proved the smart behavior of the semi‐interpenetrating polymer networks (IPNs) gels. In addition, the effect of temperature and some important biological solution on swelling behavior were reported. Cytotoxicity test demonstrated that synthesized gels owned satisfactory cytocompatibility and were convenient for the application as biomaterials. Finally, the weak bovine serum albumin (BSA) adsorption on semi‐IPNs by introducing METAC and controlling the content of PEG in gels demonstrated that they were of good protein resistance effect in biomedical applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41537.