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In Vitro evaluation and dissipative particle dynamics simulation of PLGA‐PEG‐PLGA
Author(s) -
Cao Yang,
Wang Bochu,
Yang Lichun,
Wang Yazhou,
Singh Gurinder K.
Publication year - 2015
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.41280
Subject(s) - dissipative particle dynamics , copolymer , materials science , micelle , polymer , plga , particle (ecology) , polymer chemistry , phase (matter) , chemical engineering , particle size , swelling , composite material , nanoparticle , nanotechnology , chemistry , organic chemistry , aqueous solution , oceanography , geology , engineering
Thermosensitive PLGA‐PEG‐PLGA triblock copolymers have great potential to be utilized in intravitreal injection. It is important to understand the mechanisms of selfassembled behaviors of triblock copolymers. In this study, dissipative particle dynamics simulation is used to explore the phase behaviors and morphologies of the copolymers. Phase transition, complex viscosities, swelling characteristics, and degradation behavior were investigated. The results suggested that the structures of copolymers were greatly affected by polymer concentration. Phase behavior of copolymers can be modified by alternating polymer size distribution. It exhibited that particle diameter was temperature dependence and polymer concentration can increase micelles numbers in solutions. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41280.