Premium
Design and in vitro evaluation of interpolymer complex bound metformin sustained release tablet
Author(s) -
Haque Sk Ershadul,
Sheela Angappan
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.41018
Subject(s) - thermogravimetric analysis , solubility , chitosan , polymer , fourier transform infrared spectroscopy , dissolution , controlled release , beeswax , nuclear chemistry , metformin hydrochloride , materials science , chemistry , absorption (acoustics) , polymer chemistry , chemical engineering , organic chemistry , wax , metformin , nanotechnology , composite material , medicine , endocrinology , engineering , diabetes mellitus
Metformin hydrochloride shows high solubility and incomplete absorption in biological system. To control the release pattern of such a drug, interpolymer complexes (IPCs) have a greater advantage over the individual polymers. In view of that, hydrophilic chitosan and hydroxypropyl methylcellulose (HPMC K4M) IPCs are developed at different ratios (1 : 1, 1 : 2, 1 : 3, and 1 : 4) and characterized by thermogravimetric analysis, Fourier transform infrared spectroscopy, and X‐ray diffraction studies. Different formulations (F1–F10) are developed using individual polymers and IPCs of hydrophilic polymers. Addition of hydrophobic shellac and beeswax to IPCs extends the release rate of metformin. The physical properties and drug content values of the tablets were determined and found to be within the standard limits. Based on the results of dissolution study, it is found that formulation F10 containing 1 : 4 IPC and beeswax has shown good sustained release for a period of more than 10 h. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 41018.