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Evaluation of effective parameters for the synthesis of poly(propylene fumarate) by response surface methodology
Author(s) -
Shahbazi Sara,
Jafari Yaser,
Moztarzadeh Fathollah,
Mir Mohamad Sadeghi Gity
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40932
Subject(s) - fourier transform infrared spectroscopy , propylene oxide , hydroquinone , polymer chemistry , monomer , materials science , gel permeation chromatography , response surface methodology , infrared spectroscopy , polymerization , stoichiometry , nuclear chemistry , chemistry , chemical engineering , organic chemistry , polymer , ethylene oxide , chromatography , copolymer , engineering
Poly(propylene fumarate) (PPF) is an unsaturated linear polyester, which was synthesized for potential applications in filling skeletal defects. The synthesis was carried out according to a two‐step polymerization reaction. In this research, a functional relationship among three reaction factors [temperature, reaction time, and stoichiometry of the monomers] in the PPF synthesis was established by responses of the surface methodology/central composite design (CCD). After that, on the basis of the responses of CCD [increasing intensity ratio of the CH/OH peaks in Fourier transform infrared (FTIR) spectra], designed substances were synthesized and analyzed by FTIR spectroscopy. The synthesized PPF, based on the optimized synthesis conditions from CCD, had a high molecular weight, low hydroxyl group content, and optimum viscosity. According to the CCD response, the best product was obtained through with a molar ratio of diethyl fumarate/propylene glycol/ZnCl 2 /hydroquinone of 1:3.5:0.01:0.002 and a 17‐h reaction time at 140°C. Eventually, the synthesized PPF was characterized by FTIR spectroscopy, NMR, and gel permeation chromatography analyses. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40932.