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Preparation and application in drug controlled delivery of pH‐sensitive P(CE‐ co ‐DMAEMA‐ co ‐MEG) hydrogel
Author(s) -
Wang Fang Ping,
Zhang Jun Ying,
Mu Hu Po,
Li Wan Xia,
Yuan Ting,
Du Xin Zhen
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40737
Subject(s) - swelling , self healing hydrogels , ethylene glycol , polymer chemistry , methacrylate , monomer , polymerization , nuclear chemistry , radical polymerization , materials science , chemistry , kinetics , drug delivery , chemical engineering , polymer , organic chemistry , composite material , physics , quantum mechanics , engineering
ABSTRACT A pH‐sensitive hydrogel [P(CE‐ co ‐DMAEMA‐ co ‐MEG)] was synthesized by the free‐radical crosslinking polymerization of N,N ‐dimethylaminoethyl methacrylate (DMAEMA), poly(ethylene glycol) methyl ether methacrylate(MPEG‐Mac) and methoxyl poly(ethylene glycol)‐poly(caprolactone)‐methacryloyl methchloride (PCE‐Mac). The effects of pH and monomer content on swelling property, swelling and deswelling kinetics of the hydrogels were examined and hydrogel microstructures were investigated by SEM. Sodium salicylate was chosen as a model drug and the controlled‐release properties of hydrogels were pilot studied. The results indicated that the swelling ratios of the gels in stimulated gastric fluids (SGF, pH = 1.4) were higher than those in stimulated intestinal fluids (SIF, pH = 7.4), and followed a non‐Fickian and a Fickian diffusion mechanism, respectively. In vitro release studies showed that its release rate depends on different swelling of the network as a function of the environmental pH and DMAEMA content. SEM micrographs showed homogenous pore structure of the hydrogel with open pores at pH 1.4. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40737.