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Biocompatible and biodegradable alginate/poly( N ‐isopropylacrylamide) hydrogels for sustained theophylline release
Author(s) -
Dumitriu Raluca Petronela,
Oprea AnaMaria,
Natalia Cheaburu Catalina,
Nistor ManuelaTatiana,
Novac Ovidiu,
Ghiciuc Cristina Mihaela,
Profire Lenuta,
Vasile Cornelia
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40733
Subject(s) - self healing hydrogels , theophylline , biocompatibility , drug delivery , poly(n isopropylacrylamide) , drug carrier , materials science , chemistry , polymer chemistry , chemical engineering , polymer , copolymer , nanotechnology , organic chemistry , pharmacology , medicine , engineering
Mixed‐interpenetrated polymeric networks based on sodium alginate (ALG) and poly( N ‐isopropylacryl amide) (PNIPAAm) covalently cross‐linked with N,N' ‐methylenebisacrylamide are studied for their biocompatibility, nontoxicity, and biodegradability aiming their application in drug delivery. The presence of drug‐polymeric matrix interactions and the distribution of the drug in the polymeric network for theophylline‐loaded ALG/PNIPAAm hydrogels are also investigated by spectroscopic and microscopic methods. The quantitative evaluation of theophylline loaded hydrogels performed by NIR‐CI technique shows a better drug entrapment and a higher homogeneity of the samples with increased alginate content. The thermal behavior of the hydrogels is significantly modified by theophylline presence. The application of the ALG/PNIPAAm hydrogels as carriers for sustained drug release formulations was assessed by the theophylline release tests performed both by in vitro and in vivo studies. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40733.