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Altering associations of doxorubicin‐loaded alginate esters micelles in presence of β‐cyclodextrin
Author(s) -
Zhou Qiquan,
Yang Jisheng
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40702
Subject(s) - micelle , cyclodextrin , doxorubicin , aqueous solution , emulsion , polymer , chemistry , chemical engineering , hydrophobe , materials science , polymer chemistry , biophysics , chromatography , organic chemistry , biochemistry , medicine , surgery , chemotherapy , engineering , biology
The aim of this article was to evaluate the effects of β‐cyclodextrin (β‐CD) on doxorubicin (DOX)‐loaded alginate esters (SA‐C 16 ) micelles (DOX/SA‐C 16 ) in aqueous solution. DOX was physically loaded into SA‐C 16 micelles by an o/w emulsion method with a substantial encapsulation efficiency (EE) level (36.12%), and DOX/SA‐C 16 was distributed in size diameters of approximately 254 nm. SA‐C 16 as carriers for the DOX can lead to the formation of associative networks in aqueous solutions between the hydrophobic tails of SA‐C 16 and DOX, and the dried morphology of DOX/SA‐C 16 aggregate was spherical shape. Addition of β‐CD to the system of DOX/SA‐C 16 facilitated decoupling of these associations via inclusion complex formation between β‐CD cavities and the polymer hydrophobic tails that produced the release of DOX immediately, and the EE level was dropped to 0.08%, and at the same time the size distribution of aggregate was increased to about 413 nm, moreover, the aggregate was relatively large and becoming irregular spherical shape. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40702.