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Improvement of histocompatibility of silk fibroin/polyurethane membrane with controlled release of aspirin
Author(s) -
Wang Weici,
Wang Jian,
Yang Hongjun,
Li Yiqing,
Jin Bi,
Ouyang Chenxi
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40580
Subject(s) - fibroin , aspirin , histocompatibility , materials science , polyurethane , in vivo , nuclear chemistry , chemistry , composite material , medicine , silk , immunology , antigen , human leukocyte antigen , biology , biochemistry , microbiology and biotechnology
The histocompatibility of polyurethane (PU) modified by superfine silk‐fibroin (SF) powder (1 : 1) with different dosage of aspirin to determine the best dosage for histocompatibility was investigated. Aspirin powder was incorporated into SF–PU (1 : 1) blend mixture at doses of 0%, 5%, or 10% (w/w). The influence of different doses of aspirin on histocompatibility of the hybrid material was studied by using morphology examination, infrared spectroscopy, in vitro drug release study, and in vivo tests including an acute toxicity test, an assessment of local reaction in the muscle, hematological examination, and histological examination. SF–PU (50 : 50) blend film had superior performance over the polytetrafluoroethylene (e‐PTFE) film in terms of histocompatibility, and the anti‐inflammatory/anti‐platelet effects were improved after integration with limited doses of aspirin to yield a valuable drug release vascular graft. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40580.