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Tunable degradation of piperazine‐based polyurethane ureas
Author(s) -
Ruan Changshun,
Hu Yang,
Jiang Lixin,
Cai Qingqing,
Pan Haobo,
Wang Huaiyu
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40527
Subject(s) - piperazine , degradation (telecommunications) , hexamethylene diisocyanate , polyurethane , diol , materials science , polymer , polymer chemistry , surface modification , chemical engineering , chemistry , composite material , organic chemistry , computer science , telecommunications , engineering
To manipulate the degradation of polymeric biomaterial for potential applications in tissue regeneration, a series of piperazine‐based polyurethane ureas (P‐PUUs) were designed and prepared with poly( d,l ‐lactic acid) diol (PDLLA diol), 1,6‐hexamethylene diisocyanate (HDI), and piperazine (PP). The number of piperazine units [Num(pp)] in the P‐PUUs could be precisely calculated by a specified equation and could be controlled by the regulation of the PDLLA diol/HDI/PP ratio. Then, the in vitro degradation of the P‐PUUs was investigated by the detection of the variation of the pH value, the weight loss ratio, the surface morphologies, and the molecular weight loss over 12 weeks. The results reveal that the degradation stability and the degradation rate of the P‐PUUs could be manipulated by Num(pp), and a linear correlation between the degradation rate of the P‐PUUs and Num(pp) in the polymer was demonstrated; this implied the tunable degradation of the P‐PUUs. Such a linear correlation is expected to benefit to tissue regeneration as the degradation rate of P‐PUUs for specific tissue defects can be well tuned once the tissue regenerative period is known. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40527. This article is part of a Special Issue on Bioactive Surface Functionalization. The remaining articles appear in J. Appl. Polym. Sci . (2014) volume 131, issue 14 . This note was added on 14th July 2014.