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Stabilization of pluronic gels in the presence of different polysaccharides
Author(s) -
Kjøniksen AnnaLena,
Calejo Maria Teresa,
Zhu Kaizheng,
Nyström Bo,
Sande Sverre Arne
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40465
Subject(s) - polysaccharide , poloxamer , dissolution , pectin , chitosan , aqueous solution , chemistry , cellulose , chemical engineering , biopolymer , hydroxyethyl cellulose , solubility , ethyl cellulose , chromatography , polymer chemistry , organic chemistry , polymer , copolymer , biochemistry , engineering
Several different polysaccharides have been added to pluronic F127 (poloxamer 407) gels to test their ability to stabilize the gels against dissolution in aqueous media over time. The studied polysaccharides include κ‐carrageenan, chitosan, hyaluronic acid, pectin, alginate, hydroxyethylcellulose, and ethyl(hydroxyethyl)cellulose. Although all the considered polysaccharides slowed down the dissolution time of the pluronic gels, unmodified polysaccharides only had a modest stabilization effect. However, hydrophobic modification of polysaccharides with a sufficiently long hydrocarbon chain (C 16 ) was found to partly prevent the gels from dissolving for more than 6 months. Shorter hydrocarbon chains did not have the same effect, even at high degrees of hydrophobicity. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40465.