Premium
Ultraviolet‐crosslinked hydrogel sustained‐release hydrophobic antibiotics with long‐term antibacterial activity and limited cytotoxicity
Author(s) -
Liu Tao,
Wu Ting,
Liu Hongxi,
Ke Bo,
Huang Hongxing,
Jiang Zhenyou,
Xie Mingqiang
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40438
Subject(s) - poloxamer , self healing hydrogels , antibacterial activity , cytotoxicity , photoinitiator , materials science , micelle , antibacterial agent , chemistry , polymer chemistry , antibiotics , composite material , organic chemistry , monomer , copolymer , polymer , aqueous solution , bacteria , in vitro , biochemistry , biology , genetics
To prolong erythromycin (EM) release and prevent the side effects of EM, a Pluronic F‐127 diacrylate macromer (PF127) was synthesized and then self‐assembled into micelles with their hydrophobic cores loaded with EM. The EM‐loaded micelles were mixed with a photoinitiator to form the EM/PF127 hydrogels rapidly under a low‐intensity UV light. Afterward, the hydrogel properties, antibacterial performance, and cytotoxicity of this novel hybrid hydrogel were investigated. The results show that the EM/PF127 hydrogel had a rapid gelation time. The sustained release of EM reduced its side effects. With controlled antibacterial activity, the use of EM would be safer and more efficient. What is more, the EM/PF127 hydrogel showed a slight cytotoxicity, and this suggests great potential application as antibacterial hydrogels in the prevention of postoperative infection. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40438.