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Synthesis and characterization of a drug‐delivery system based on melamine‐modified poly(vinyl acetate‐ co ‐maleic anhydride) hydrogel
Author(s) -
Shafaghi Samira,
Moghadam Peyman Najafi,
Fareghi Amir Reza,
Baradarani Mohammad Mehdi
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40389
Subject(s) - self healing hydrogels , maleic anhydride , melamine , polymer chemistry , drug delivery , copolymer , vinyl acetate , materials science , differential scanning calorimetry , fourier transform infrared spectroscopy , chemical engineering , nuclear chemistry , chemistry , polymer , composite material , nanotechnology , physics , engineering , thermodynamics
Three‐dimensional polymeric networks, which quickly swell by imbibing a large amount of water or deswell in response to changes in their external environment, are called hydrogels . These types of polymeric materials are good potential candidates for drug‐delivery systems. In this study, we first synthesized poly(vinyl acetate‐ co ‐maleic anhydride) by free‐radical copolymerization. Then, they were modified with different molar ratios of melamine to prepare hydrogels that could be used in drug‐delivery systems. The hydrogels were characterized by Fourier transform infrared spectroscopy, 1 H‐NMR, differential scanning calorimetry, and scanning electron microscopy. In the second step, Ceftazidime antibiotic was loaded on selected hydrogels. The in vitro drug release was investigated and compared in three different media (HCl solution at pH = 3 and buffer solutions at pH 6.1and pH 8). © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40389.