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MS‐monitored conjugation of poly(ethylene glycol) monomethacrylate to RGD peptides
Author(s) -
Bol'shakov Oleg I.,
Akala Emmanuel O.
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40385
Subject(s) - ethylene glycol , polymer , peg ratio , combinatorial chemistry , drug delivery , materials science , adhesion , chemistry , polymer chemistry , nanotechnology , organic chemistry , finance , economics
Development of biologically active polymers is an active area of research due to their applications in varied and diverse fields of biomedical research: cell adhesion, tissue proliferation, and drug delivery. Recent advances in chemical modification allow fine‐tuning of the properties of biomedical polymers to improve their applications: blood circulation half‐life, stimuli‐responsive degradation, site‐specific targeting, drug loading, etc. In this article, convergent synthesis of polymerizable macromonomers bearing a site‐specific ligand (RGD peptide) using a low molecular weight MA‐poly(ethylene glycols) (PEGs) is presented. The method affords macromonomers useful as the starting materials to produce biomedical polymers. We found matrix assisted laser desorption/ionization mass spectromerty convenient in monitoring the conjugation process via step‐by‐step following of PEG modification. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40385.