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Impacts of PEGylation on the gene and oligonucleotide delivery system
Author(s) -
Ikeda Yutaka,
Nagasaki Yukio
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40293
Subject(s) - pegylation , oligonucleotide , peg ratio , ethylene glycol , liposome , gene delivery , drug delivery , nuclease , materials science , chemistry , combinatorial chemistry , nanotechnology , genetic enhancement , polyethylene glycol , gene , biochemistry , organic chemistry , finance , economics
Poly(ethylene glycol) (PEG) is the most widely used polymer and also the gold standard in the field of drug delivery. Therapeutic oligonucleotides, for example, are modified with PEG at the terminus to increases nuclease resistance and the circulating half‐lives. The surface of nanoparticle such as micelle and liposome has been also modified with PEG. At present, one PEGylated therapeutic oligonucleotide has been approved for the market and several more PEGylated products including oligonucleotide and liposome are being tested in clinical settings. This review summarizes the methods and effects of PEGylation on gene delivery. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40293.