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Regeneration effect of visible light‐curing furfuryl alginate compound by release of epidermal growth factor for wound healing application
Author(s) -
Heo Yun,
Lee HyungJae,
Kim EunHye,
Kim MiKyung,
Ito Yoshihiro,
Son TaeIl
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40113
Subject(s) - wound healing , rose bengal , materials science , curing (chemistry) , visible spectrum , epidermal growth factor , chemistry , regeneration (biology) , nuclear chemistry , biomedical engineering , polymer chemistry , organic chemistry , biochemistry , surgery , biology , medicine , microbiology and biotechnology , receptor , optoelectronics
A visible light‐curable polysaccharide conjugate was prepared and was included with epidermal growth factor (EGF) for wound healing application. Alginate was modified with furfurylamine, and the furfuryl alginate (F‐alginate) was mixed with Rose Bengal for visible light reactivity. The introduction of furfuryl group was confirmed by 1 H‐NMR and UV/vis spectroscopy. Visible light‐induced crosslinking was evaluated by micropatterning and weight measurement. Swelling ratio was also determined. To verify its applicability in wound healing applications, EGF was included in the system of F‐alginate and Rose Bengal. After the confirmation of no cytotoxicity of F‐alginate and murine EGF release from the system, cell proliferation, antibacterial activity, and animal test were performed on the system. In conclusion, it was demonstrated that the system was useful for wound healing. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40113.