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Microparticles based on hydrophobically modified chitosan as drug carriers
Author(s) -
Calejo Maria Teresa,
Kjøniksen AnnaLena,
Maleki Atoosa,
Nyström Bo,
Sande Sverre Arne
Publication year - 2014
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.40055
Subject(s) - chitosan , plga , polymer , drug delivery , drug carrier , chemistry , chemical engineering , solvent , polymer chemistry , materials science , nanoparticle , organic chemistry , nanotechnology , engineering
In this work, a hydrophobically modified (HM) chitosan derivative was prepared by covalent linkage of C 12 groups to the chitosan backbone. HM‐chitosan microparticles were prepared according to an emulsification‐solvent evaporation method and naltrexone (NTX) was used as a model drug. For comparison, unmodified chitosan and poly lactic‐ co ‐glycolic acid (PLGA) microparticles were also tested as carriers for NTX. HM‐chitosan formed viscous semi‐dilute solutions, suggesting a high level of chain entanglements and hydrophobic associations. HM‐chitosan microparticles generally showed higher production yield and encapsulation efficiency, as compared with chitosan and PLGA. The burst release shown by chitosan microparticles was significantly reduced when using the HM‐chitosan derivative. An enhanced control of drug release was observed over at least 50 days. PLGA particles demonstrated inferior controlled release properties as compared to HM‐chitosan subsequent to the initial release stage. These results revealed the potential of hydrophobic modification of chitosan as a means to improve the stability and sustained delivery properties of the polymer. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40055.