Synthesis and characterization of poly(caprolactone triol succinate) elastomer for tissue engineering application | Zendy

Harmon Matthew D. | Zendy; James Roshan | Zendy; Shelke Namdev B. | Zendy; Kumbar Sangamesh G. | Zendy

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Synthesis and characterization of poly(caprolactone triol succinate) elastomer for tissue engineering application

Author(s) -

Harmon Matthew D.,

James Roshan,

Shelke Namdev B.,

Kumbar Sangamesh G.

Publication year - 2013

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.39633

Subject(s) - caprolactone , elastomer , polycaprolactone , triol , materials science , osteoblast , alkaline phosphatase , polymer chemistry , polyester , ultimate tensile strength , polymer , elongation , adhesion , condensation polymer , tissue engineering , polybutylene succinate , in vitro , chemical engineering , chemistry , copolymer , biomedical engineering , diol , biochemistry , composite material , enzyme , medicine , engineering

A novel polymer poly(caprolactone triol succinate) (PPCLSu) was synthesized from monomers polycaprolactone triol and succinic acid by direct polycondensation. The tensile strength of PPCLSu was found to be 0.33 ± 0.03 MPa with an elongation of 47.8 ± 1.9%. These elastomers lost about 7% of their original mass in an in vitro degradation study conducted in phosphate‐buffered saline (PBS) at 37°C up to 10 weeks. Three‐dimensional (3D) porous scaffolds were created by a porogen‐leaching method and these constructs were evaluated for primary rat osteoblast (PRO) proliferation and phenotype development in vitro . This elastomer promoted primary rat osteoblast adhesion, proliferation and increased expression of alkaline phosphatase, an early marker of osteoblastic phenotype. These preliminary results suggest that PPCLSu may be a good candidate material for scaffolding applications in tissue regeneration. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3770–3777, 2013

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