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Chitosan‐based wet‐spun scaffolds for bioactive agent delivery
Author(s) -
Ucar Seniz,
Yilgor Pinar,
Hasirci Vasif,
Hasirci Nesrin
Publication year - 2013
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.39629
Subject(s) - chitosan , scaffold , regeneration (biology) , drug delivery , tissue engineering , materials science , controlled release , biomedical engineering , chemistry , nanotechnology , organic chemistry , medicine , biology , microbiology and biotechnology
Use of scaffolds both as supporting materials at defect site and delivery vehicles for bioactive agents is a commonly employed strategy to aid in tissue repair and regeneration. In this study, fibrous meshes of chitosan were prepared by wet spinning and coated with alginate. BSA as a model protein and gentamicin as a model antibiotic were incorporated into the scaffolds in multiple loading models and their release kinetics were studied. The effects of structural form of scaffold and properties of bioactive agents on release profiles were evaluated. Our results suggest that, designed scaffolds are potential candidates for tissue engineering with the feature of controlled bioactive agent delivery. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3759–3769, 2013